DATA RELEASES

Release: 2018.02 30 July 2018

• Data
  • HREM annotation data added for Ehbp1l1, Frrs1, Pitx1, Pthlh.
  • E18.5 nervous sytem images added for 1700067K01Rik, Arid1b, Coro1c, Crim1, Cyfip2, Slc20a2.
• Website changes
  • Embryo DMDD IDs can be listed in the summary tables on the line pages.
  • Miscellaneous UX changes.
• New content
  • New protocol pages added for mouse heart isolation, blood removal and embryo harvesting.
• Allele nomenclature changes
  • Mir96^{tm2.2(IMPC)Wtsi} renamed Mir96^tm2.2Wtsi
  • Xbp1^{tm1a(EUCOMM)Wtsi/Ics} renamed Xbp1^{tm1a(EUCOMM)Wtsi}

Release: 2018.01 11 June 2018

• Data
  • HREM image data added for Auts2, Col4a2, Ehbp1l1, Frrs1, Gtpbp3, Nr0b1, Pitx1, Pthlh mutant lines.
  • HREM annotation data added for Auts2, B9d2, Col4a2, Dcx, Morc2a, Zmynd11.
  • Placenta data added for Brd2, Camsap3, Gtpbp3, Pdzk1, Slc25a20.
  • A revised list of early lethal lines. Due to the number of embryos studied 9 lines: Ddx23, Ddx51, Eif2b2, Esco2, Mrpl23, Ncaph2, Nrde2, Pwp1, Vps72 are no longer listed as early lethals. All the data used to determine viability is listed in the new embryonic viability table.
• Website changes
  • MailChimp mailing forms removed.
  • Usersnap feedback form removed.
  • Ammended privacy policy.
  • Miscellaneous UX changes.
• New content
  • Embryonic viability is reported at E9.5 and E14.5 for mutant lines.
  • Immunofluorescent and nissl stained images of the E18.5 nervous sytem (see Trappc9).
• Gene nomenclature updates
  • Fam46c renamed Tent5c
  • 9130011E15Rik renamed Armh3
• Allele nomenclature changes
  • Brd2^em2Wtsi renamed Brd2^{em1(IMPC)Wtsi}
  • Cfap53^em2Wtsi renamed Cfap53^{em1(IMPC)Wtsi}
  • Crim1^em1Wtsi renamed Crim1^{em1(IMPC)Wtsi}
  • Fut8^em1Wtsi renamed Fut8^{em1(IMPC)Wtsi}
  • Mir96^Tm2.2WTSI renamed Mir96^{tm2.2(IMPC)Wtsi}
• Ontology
  • The Mammalian Phenotype Ontology has been updated to version 20180212.

Release: 2017.03 24 November 2017

• Data
  • HREM image data added for B9d2, Cnot4, Dcx, Flvcr2, Morc2a, Zmynd11 mutant lines.
  • HREM annotation data added for Cbx6, Cc2d2a, Flvcr2, Oaz1.
  • Placenta data added for Flvcr2, Hmgxb3, Prmt7, Virma.
  • 5 additional early lethal lines identified.
• Website changes
  • Icons indicate annotated embryos in the stackviewer.
  • Improved print layout.
  • Miscellaneous UX changes.
• New content
  • P14 viability is reported for mutant lines.
  • The Theiler stage of an embryo is listed where assessed.
  • The voxel size of each HREM image stack is shown.
  • 2000 additional images of the placenta and yolk sac show the distribution of E-Cadherin protein, Tpbpa RNA and Isolectin BSI-B4.
  • New page linking to reference wild-type atlases.

Release: 2017.02 14 July 2017

• Data
  • HREM image data added for Cbx6, Cc2d2a, Hmgxb3, Oaz1, Prmt7, Xpnpep1 mutant lines.
  • HREM annotation data added for Hmgxb3, Prmt7, Xpnpep1.
  • Placenta data added for Mir96.
  • 27 additional early lethal lines identified.
• Website changes
  • Interactive link to the Kaufman Atlas hosted at EMAP added on the stackviewer page.
  • Reorganisation of the line summary tables to generate E14.5 and E9.5 summaries.
• New content
  • The sex of embryos determined by morphological and molecular techniques is reported.

Release: 2017.01 6 March 2017

• Data
  • HREM image data added for Dennd4c, Dnajc8, Pigf mutant lines.
  • HREM annotation data added for Actn4, Arid1b, Cfap53, Cyp11a1, Dmxl2, Fut8, Mfsd7c.
  • Placenta data added for B9d2, Cbx6, Commd10, Coq4, Dcx, Dhx35, Fam160a1, Gpatch1, Mfsd7c, Oaz1, Smg1.
  • 60 early lethal lines identified
  • Embryo phenotype annotations dataset
• Nomenclature updated to reflect MGI status
  • Fam21 renamed Washc2.
• Website changes
  • Search by anatomical term using mouse (EMAPA and MA) and human (EHDAA2 and FMA) ontologies
  • Search results now include early embryonic lethal genes
  • Search results now include genes not studied by DMDD, but with embryo data on the IMPC website
• New content
  • New protocol page detailing phenotyping at E14.5
  • Page on gene expression profiling of mutant embryos, with initial 11 lines
  • Early lethals page with listing and download
  • Embryo phenotype annotations - listing and download

Release: 2016.04 30 November 2016

• Data
  • HREM image data added for Actn4, Arid1b, Cfap53, Crim1, Cyp11a1, Dmxl2, Fut8, Gas2l2, Mfsd7c, Rala mutant lines.
  • HREM annotation data added for Atg16l1, Capza2, Coro1c, Crim1, Cyfip2, Gas2l2, Gm5544, Rala, Rpgrip1l, Syt1, Trim45.
  • Placenta data added for Arhgef7, Arid1b, Fam21, Fut8, Med23, Timmdc1.
• Nomenclature updated to reflect MGI status
  • Suv420h1 renamed Kmt5b.

MAJOR WEBSITE REVISION

• Font change
  • The body font was changed from serif to sans serif with improved letter spacing to make it easier to read.
• News
  • News separated from releases, with images where relevant. The dedicated news page highlights new content on the website and the DMDD blog, upcoming events we'll be attending, and the DMDD social channels.
• Homepage
  • Reduced the height of the page to make it easier to see all the content on laptop devices.
  • Made the background image on the homepage much larger and more of a feature, at the same time reducing file sizes of these random images.
  • Added 'ticker' text to the homepage, providing easily scannable bite size chunks about the DMDD programme, told in a logical 'story'.
  • Added search box to the homepage enabling users to easily search for genes or phenotypes, without having to click on a button in the navigation.
  • Added newsletter signup to the homepage to encourage users to signup to receive regular newsletter updates.
• Navigation
  • Changed the global navigation menu at the top of the page to a 'mega menu' that provides users with more information about the sections of the website, to help ensure that where they end up is where they intended to be, and also makes it easier to discover other parts of the website.
• New and revised content, especially:
  • About the DMDD programme
  • DMDD pipeline
  • About the mutants
  • Wild-type gene expression profiling
  • Research protocols added, as well as new section on HREM.
  • Communications materials page created with downloadable, shareable assets.
• CSS styling review and tidy up
• Embryo page
  • Removed accordion to make it more immediately apparent what data is available for each embryo at a glance (without multiple clicks).
• Feedback link
  • Moved from RHS of all pages, where it was missed, to within the 'utilities' section at the top right of each page, where users expected to find it.
• Added initial favicon.ico

Release: 2016.03 05 August 2016

• Data
  • HREM image data added for Atg16l1, Capza2, Cog6, Coro1c, Cyfip2, Dhx35, Gm5544, Nadk2, Nrbp1, Rab21, Rpgrip1l, Syt1 mutant lines.
  • HREM annotation data added for Adamts3, Brd2, Cog6, Cpt2, Dhx35, H13, Mir96, Npat, Nsun2, Pdzk1.
  • Placenta data added for 1110037F02Rik, Actn4, Atg16l1, Camsap3, Capza2, Cfap53, Coro1c, Crim1, Crls1, Cyfip2, Dmxl2, Gm5544, Gtpbp3, H13, Nsun2, Rab21, Rala, Rpgrip1l, Syt1, Trim45.
• Genotypes
  • The genotypes of some embryos and placenta have been corrected in this release.

Release: 2016.02 03 May 2016

• Data
  • HREM image data added for Brd2, Camsap3, Col4a3bp, Cpt2, Eif3h, H13, Mir96, Npat, Nsun2, Pdzk1, Smg9, and Trim45 mutant lines.
  • HREM annotation data added for Adamts3, Camsap3, Col4a3bp, Duoxa2, Smg9, Ssr2, Traf2, and Trappc9.
  • HREM annotation data restored for Dbn1, Exoc3l2, Ogdh, and Slc5a7.
  • Placenta data added for Brd2, Cnot4, Cog6, Col4a3bp, Cpt2, Cyp11a1, Pdzk1, Pgap2, Smg9, and Wrap53.
• External Links
  • Links to MGI updated to adopt a stable URL format.

Release: 2016.01 23 February 2016

• Data
  • HREM image data added for Adamts3, Duoxa2, Ssr2, Trappc9 mutant lines.
  • HREM annotation data added for 4933434E20Rik, Adcy9, Myo9a, Otud7b, Sh3pxd2a, Slc20a2, Unk.
  • HREM annotation data temporarily removed for Dbn1, Exoc3l2, Ogdh, and Slc5a7.
  • Placenta data added for Adamts3, Adcy9, Dennd4c, Dnajc8, Duoxa2, Eif3h, Nadk2, Nhlrc2, Nrbp1, Otud7b, Pigf, Pigl, Slc20a2, Trappc9 .
• Nomenclature updated to reflect MGI status
  • 2510003E04Rik renamed Kif1bp.
  • Trp53rk renamed Trp53rkb.
• Ontology
  • The Mammalian Phenotype Ontology has been updated to version 20160205 that incorporates almost all DMDD CV terms.
• The DMDD CV now describes:
  • hemangioma
  • retrolental blood
  • abnormal lung vein connection

Release: 2015.11 25 November 2015

• Data
  • HREM image data added for Adcy9, Akap9, Aldh18a1, Amfr, Arid2, Arid4a, Asxl1, Cenpj, Cntfr, Csrp2bp, Dscc1, Ehd1, Fam134c, Hdac1, Hp1bp3, Ikbkb, Jarid2, Lmnb2, Ltbp1, Mbtd1, Mks1, Nf1, Otud7b, Pds5b, Prkab1, Prmt3, Rhot1, Slc20a2, Srsf4, Supv3l1, Suv420h1, Unk, Zc3hc1 mutant lines.
  • Removed the mutant lines Epc2, Pnpo, Ralgapb, Seh1l, Tmod1 - poor quality data.
  • HREM image data for wild-type stages E11.5, E12.5, and E15.5, and additional data for wild-type stages E9.5, E10.5, E13.5, and E14.5.
  • Placenta data added for 1700007K13Rik, Denr, Dhodh, Dpm1, Fryl, Nek9, Setd5, Sh3pxd2a, Ssr2, and Unk.
• Downloads
  • Download buttons changed to Excel format to support UTF8, allowing formatting of allele name.
  • Download files named according to specific data requested.
• Line page
  • Added ability to switch between carousel view and grid view on the line page to easily view all thumbnails.
  • Added tooltip to embryo thumbnails highlighting data available for each embryo on the line page.
  • Added placenta-specific thumbnails.

Release: 2015.10 2 October 2015

• Improved reporting of genotypes
  • Genotype shown rather than an abbreviation
  • Added a tooltip to the genotype abbreviation symbol where space constraints
• Fixed the display of arrows on the search, embryo page and stackviewer help
• Added links to programme partners
• Updated the DMDD workflow diagram to change NIMR to the Crick

Release: 2015.09 18 August 2015

• HREM image data for Myo9a mutants, additional E13.5 wild-type embryos, and human embryos
• HREM annotation data for 1700007K13Rik, Anks6, Fam46c, Psph
• Placenta data added for 1700007K13Rik, 4933434E20Rik, Anks6, Celf4, Ddx42, Denr, Dpm1, Fam46c, Kif3b, Myo9a, Psph, Setd5, Sh3pxd2a
• Line phenotype summary buttons added to the gene page
• Download option added to search results and tabular data
• Improved gene page carousel navigation

Release: 2015.08 1 July 2015

• HREM image data for 1700007K13Rik, 4933434E20Rik, Anks6, Celf4, Fam46c, Polb, Psph, Sh3pxd2a
• HREM annotation data for 1700067K01Rik, Celf4, Polb, Setd5
• Consistent table styling
• Added high level terms to improve the search function
• Responsive global navigation

Release: 2015.07 18 May 2015

• HREM image data for Psph
• HREM annotation data for Prrc2b
• Additional placenta data for Psph, Chop, Nek9, Vps33b
• Symbol update: Jmjd5 is now a synonym of Kdm8
• Added gene synonyms to the gene listing page and individual gene pages
• Added icons to the gene listing page to indicate the availability of data for each gene
• Added help tour to individual gene pages
• Simplified search user interface

DMDD website launch April 2015

• Modern new design for website
• New interactive tools for viewing embryo data
• Comprehensive search functions
• Standardised phenotype data available
• Summaries for mutant lines
• Placenta images and phenotyping