DMDD Fam160a1 report

Fam160a1^{tm1b(EUCOMM)Wtsi}

gene synonyms

LINE VIABILITY: Lethal

SHOW LINE PHENOTYPES

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E9.5 -/- DMDD7647_placenta

Placenta

Ⓟ DMDD7647 data

E9.5 -/- DMDD7646_placenta

Placenta

Ⓟ DMDD7646 data

E9.5 -/- DMDD7645_placenta

Placenta

Ⓟ DMDD7645 data

E9.5 +/+ DMDD7649_placenta

Placenta

Ⓟ DMDD7649 data

E9.5 +/+ DMDD7648_placenta

Placenta

Ⓟ DMDD7648 data

E9.5 +/+ DMDD7644_placenta

Placenta

Ⓟ DMDD7644 data

HREM

Ⓟ PLACENTA PHENOTYPES

EMBRYO PHENOTYPES

SAMPLE INFORMATION

DMDD7647 E9.5

Single page view for DMDD7647

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0001716	abnormal placenta labyrinth morphology
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology
MP:0005031	abnormal trophoblast layer morphology
MP:0008803	abnormal placental labyrinth vasculature morphology

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Female
DMDD ID	DMDD7647
Sanger ID	MUGP65.1b
Order mouse	Order mouse from IMPC

DMDD7646 E9.5

Single page view for DMDD7646

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0001716	abnormal placenta labyrinth morphology
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology
MP:0008803	abnormal placental labyrinth vasculature morphology
MP:0005031	abnormal trophoblast layer morphology

Yolk sac

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Female
DMDD ID	DMDD7646
Sanger ID	MUGP51.1g
Order mouse	Order mouse from IMPC

DMDD7645 E9.5

Single page view for DMDD7645

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0001716	abnormal placenta labyrinth morphology
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology
MP:0005031	abnormal trophoblast layer morphology
MP:0008803	abnormal placental labyrinth vasculature morphology

Yolk sac

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Male
DMDD ID	DMDD7645
Sanger ID	MUGP51.1a
Order mouse	Order mouse from IMPC

DMDD7649 E9.5

Single page view for DMDD7649

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Male
DMDD ID	DMDD7649
Sanger ID	MUGP65.1g
Order mouse	Order mouse from IMPC

DMDD7648 E9.5

Single page view for DMDD7648

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Male
DMDD ID	DMDD7648
Sanger ID	MUGP65.1c
Order mouse	Order mouse from IMPC

DMDD7644 E9.5

Single page view for DMDD7644

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Fam160a1
Allele	Fam160a1^{<tm1b(EUCOMM)Wtsi>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Female
DMDD ID	DMDD7644
Sanger ID	MUGP46.1d
Order mouse	Order mouse from IMPC

FIRST TIME HERE?

We recommend you take the 30 second page tour which provides an overview of the page functionality.
1/7 CAROUSEL

This shows all the embryos available for the line.
2/7 LINE SUMMARY

Phenotype data for the LINE can be viewed by clicking this button.
3/7 EMBRYO DATA

The lower part of the page shows all the data available for the sample highlighted in red.
4/7 DATA TABS

The tabs show different types of data collected for each sample.
5/7 PLACENTA PHENOTYPES ICONS

Availability of placental phenotype data is indicated by Ⓟ in the carousel above.
6/7 EMBRYO PHENOTYPES ICONS

Availability of embryo phenotype data is indicated by in the carousel above.
7/7 TOUR END

That's the end of the page tour. You can retake it anytime by clicking on the help icon.

30 SECOND PAGE TOUR

Provides an overview of line page functionality.
1/7 CAROUSEL

This shows all the embryos available for the line.
2/7 LINE SUMMARY

Phenotype data for the LINE can be viewed by clicking this button.
3/7 EMBRYO DATA

The lower part of the page shows all the data available for the sample highlighted in red.
4/7 DATA TABS

The tabs show different types of data collected for each sample.
5/7 PLACENTA PHENOTYPES ICON

Availability of placental phenotype data is indicated by Ⓟ in the carousel above.
6/7 EMBRYO PHENOTYPES ICON

Availability of embryo phenotype data is indicated by in the carousel above.
7/7 TOUR END

That's the end of the page tour. You can retake it anytime by clicking on the help icon.

Fam160a1tm1b(EUCOMM)Wtsi

LINE VIABILITY: Lethal

PLACENTA PHENOTYPES (homozygous mutants)

E9.5 PLACENTA PHENOTYPES (homozygous mutants)

E14.5 PLACENTA PHENOTYPES (homozygous mutants)

EMBRYO PHENOTYPES (homozygous mutants)

E9.5 EMBRYO PHENOTYPES (homozygous mutants)

E14.5 EMBRYO PHENOTYPES (homozygous mutants)

DMDD7647 E9.5

Fam160a1<tm1b(EUCOMM)Wtsi>/Fam160a1<tm1b(EUCOMM)Wtsi>

Placenta

Images

DMDD7646 E9.5

Fam160a1<tm1b(EUCOMM)Wtsi>/Fam160a1<tm1b(EUCOMM)Wtsi>

Placenta

Yolk sac

Images

DMDD7645 E9.5

Fam160a1<tm1b(EUCOMM)Wtsi>/Fam160a1<tm1b(EUCOMM)Wtsi>

Placenta

Yolk sac

Images

DMDD7649 E9.5

+/+

Placenta

Images

DMDD7648 E9.5

+/+

Placenta

Images

DMDD7644 E9.5

+/+

Placenta

Images

FIRST TIME HERE?

1/7 CAROUSEL

2/7 LINE SUMMARY

3/7 EMBRYO DATA

4/7 DATA TABS

5/7 PLACENTA PHENOTYPES ICONS

6/7 EMBRYO PHENOTYPES ICONS

7/7 TOUR END

30 SECOND PAGE TOUR

1/7 CAROUSEL

2/7 LINE SUMMARY

3/7 EMBRYO DATA

4/7 DATA TABS

5/7 PLACENTA PHENOTYPES ICON

6/7 EMBRYO PHENOTYPES ICON

7/7 TOUR END

Fam160a1^{tm1b(EUCOMM)Wtsi}

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}

Fam160a1^{<tm1b(EUCOMM)Wtsi>}/Fam160a1^{<tm1b(EUCOMM)Wtsi>}