DMDD Bap1 report

Bap1^{tm1a(EUCOMM)Hmgu}

gene synonyms

LINE VIABILITY: Lethal

SHOW LINE PHENOTYPES

Carousel view

Grid view

E9.5 -/- DMDD7153_placenta

Placenta

Ⓟ DMDD7153 data

E9.5 -/- DMDD7151_placenta

Placenta

Ⓟ DMDD7151 data

E9.5 -/- DMDD7150_placenta

Placenta

Ⓟ DMDD7150 data

E9.5 +/+ DMDD7154_placenta

Placenta

Ⓟ DMDD7154 data

E9.5 +/+ DMDD7152_placenta

Placenta

Ⓟ DMDD7152 data

E9.5 +/+ DMDD7149_placenta

Placenta

Ⓟ DMDD7149 data

HREM

Ⓟ PLACENTA PHENOTYPES

EMBRYO PHENOTYPES

SAMPLE INFORMATION

DMDD7153 E9.5

Single page view for DMDD7153

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Female
DMDD ID	DMDD7153
Sanger ID	MGGV74.1h
Order mouse	Order mouse from IMPC

DMDD7151 E9.5

Single page view for DMDD7151

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology

Yolk sac

ID	MP TERM
MP:0001718	abnormal visceral yolk sac morphology

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Female
DMDD ID	DMDD7151
Sanger ID	MGGV65.1h
Order mouse	Order mouse from IMPC

DMDD7150 E9.5

Single page view for DMDD7150

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002836	abnormal chorion morphology
MP:0005033	abnormal trophoblast giant cell morphology

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Not determined
Comments on sex	Potential sex reversal
DMDD ID	DMDD7150
Sanger ID	MGGV53.1c
Order mouse	Order mouse from IMPC

DMDD7154 E9.5

Single page view for DMDD7154

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Male
DMDD ID	DMDD7154
Sanger ID	MGGV74.1i
Order mouse	Order mouse from IMPC

DMDD7152 E9.5

Single page view for DMDD7152

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Yolk sac

ID	MP TERM
MP:0001718	abnormal visceral yolk sac morphology

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Immunohistochemistry	E-CadherinView placenta image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window
Yolk sac immunofluorescence	Green: E-Cadherin Red: Laminin Blue: DAPIView yolk sac image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Not determined
Comments on sex	Potential sex reversal
DMDD ID	DMDD7152
Sanger ID	MGGV72.1a
Order mouse	Order mouse from IMPC

DMDD7149 E9.5

Single page view for DMDD7149

+/+

No HREM data is available for this embryo.

Placenta

ID	MP TERM
MP:0002169	no abnormal phenotype detected

Images

IMAGE TYPE	PROBE/ANTIGEN PROBE/ANTIGEN E-Cadherin (Cdh1) was used to demarcate syncytiotrophoblast in the placental labyrinth at E9.5, and to label parietal trophoblast giant cells. Isolectin BSI-B4 was used to highlight the placental labyrinth and the decidua. Tpbpa was used to mark spongiotrophoblast and glycogen cells. Yolk sacs were stained for E-Cadherin (green), Laminin (red) and DAPI. E-Cadherin labels the visceral yolk sac endoderm, Laminin labels the basement membrane between endoderm and mesoderm layers. ×	IMAGE
Hematoxylin and eosin	View placenta image at full resolution in a new window
In situ hybridisation	TpbpaView placenta image at full resolution in a new window

PROPERTY	VALUE
Type	Mutant line
Viability of the line at P14	Lethal
Gene	Bap1
Allele	Bap1^{<tm1a(EUCOMM)Hmgu>}
Genotype	+/+
Strain	C57BL/6N; C57BL/6NTac
Stage	E9.5
Sex (morphological analysis)	Not determined
Sex (PCR analysis)	Male
DMDD ID	DMDD7149
Sanger ID	MGGV53.1a
Order mouse	Order mouse from IMPC

FIRST TIME HERE?

We recommend you take the 30 second page tour which provides an overview of the page functionality.
1/7 CAROUSEL

This shows all the embryos available for the line.
2/7 LINE SUMMARY

Phenotype data for the LINE can be viewed by clicking this button.
3/7 EMBRYO DATA

The lower part of the page shows all the data available for the sample highlighted in red.
4/7 DATA TABS

The tabs show different types of data collected for each sample.
5/7 PLACENTA PHENOTYPES ICONS

Availability of placental phenotype data is indicated by Ⓟ in the carousel above.
6/7 EMBRYO PHENOTYPES ICONS

Availability of embryo phenotype data is indicated by in the carousel above.
7/7 TOUR END

That's the end of the page tour. You can retake it anytime by clicking on the help icon.

30 SECOND PAGE TOUR

Provides an overview of line page functionality.
1/7 CAROUSEL

This shows all the embryos available for the line.
2/7 LINE SUMMARY

Phenotype data for the LINE can be viewed by clicking this button.
3/7 EMBRYO DATA

The lower part of the page shows all the data available for the sample highlighted in red.
4/7 DATA TABS

The tabs show different types of data collected for each sample.
5/7 PLACENTA PHENOTYPES ICON

Availability of placental phenotype data is indicated by Ⓟ in the carousel above.
6/7 EMBRYO PHENOTYPES ICON

Availability of embryo phenotype data is indicated by in the carousel above.
7/7 TOUR END

That's the end of the page tour. You can retake it anytime by clicking on the help icon.

Bap1tm1a(EUCOMM)Hmgu

LINE VIABILITY: Lethal

PLACENTA PHENOTYPES (homozygous mutants)

E9.5 PLACENTA PHENOTYPES (homozygous mutants)

E14.5 PLACENTA PHENOTYPES (homozygous mutants)

EMBRYO PHENOTYPES (homozygous mutants)

E9.5 EMBRYO PHENOTYPES (homozygous mutants)

E14.5 EMBRYO PHENOTYPES (homozygous mutants)

DMDD7153 E9.5

Bap1<tm1a(EUCOMM)Hmgu>/Bap1<tm1a(EUCOMM)Hmgu>

Placenta

Images

DMDD7151 E9.5

Bap1<tm1a(EUCOMM)Hmgu>/Bap1<tm1a(EUCOMM)Hmgu>

Placenta

Yolk sac

Images

DMDD7150 E9.5

Bap1<tm1a(EUCOMM)Hmgu>/Bap1<tm1a(EUCOMM)Hmgu>

Placenta

Images

DMDD7154 E9.5

+/+

Placenta

Images

DMDD7152 E9.5

+/+

Placenta

Yolk sac

Images

DMDD7149 E9.5

+/+

Placenta

Images

FIRST TIME HERE?

1/7 CAROUSEL

2/7 LINE SUMMARY

3/7 EMBRYO DATA

4/7 DATA TABS

5/7 PLACENTA PHENOTYPES ICONS

6/7 EMBRYO PHENOTYPES ICONS

7/7 TOUR END

30 SECOND PAGE TOUR

1/7 CAROUSEL

2/7 LINE SUMMARY

3/7 EMBRYO DATA

4/7 DATA TABS

5/7 PLACENTA PHENOTYPES ICON

6/7 EMBRYO PHENOTYPES ICON

7/7 TOUR END

Bap1^{tm1a(EUCOMM)Hmgu}

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}

Bap1^{<tm1a(EUCOMM)Hmgu>}/Bap1^{<tm1a(EUCOMM)Hmgu>}